Southeast Missouri Vacation Packages

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Flight and hotel packages to Southeast Missouri

Price found within the past 48 hours. Click for updated prices.
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
Woodson Terrace
per person
Jun 10 - Jun 12
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, express check-in, and free airport shuttle. A free area shuttle is offered as well.
Crowne Plaza St. Louis Airport, an IHG Hotel

Crowne Plaza St. Louis Airport, an IHG Hotel

3.5 out of 5
per person
Jun 10 - Jun 13
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and free airport shuttle. Enjoy the gym and perks like a free area shuttle.
Moonrise Hotel

Moonrise Hotel

4 out of 5
per person
Jun 10 - Jun 12
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. Enjoy a meal from the a restaurant and perks like free self parking.
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
Downtown St. Louis
per person
Jun 10 - Jun 13
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center, express check-in, and valet parking. Self parking, express check-out, and a computer station are also offered.
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
per person
Jul 11 - Jul 14
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
This luxury hotel features a casino, a full-service spa, and 5 restaurants. Enjoy the 2 spa tubs and 24-hour gym, and unwind with a drink at the poolside bar.

Top Southeast Missouri hotel deals

Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5
3265 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $72 per night
$72
per night
May 26 - May 27
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
The price is $57 per night
$57
per night
May 12 - May 13
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
The price is $77 per night
$77
per night
May 6 - May 7
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $117 per night
$117
per night
May 19 - May 20
This hotel features an indoor pool, a spa tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
Hot Tub
Pet friendly
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
The price is $67 per night
$67
per night
Jun 2 - Jun 3
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A gym and a safe deposit box are also provided.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
The price is $108 per night
$108
per night
May 19 - May 20
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit in Southeast Missouri

Image for Meramec Caverns

Meramec Caverns

5/5(21 reviews)

Explore the great outdoors at Meramec Caverns, a lovely green space in Sullivan. While in this family-friendly area, you can enjoy the coffeehouses.

Meramec Caverns
Image for Elephant Rocks State Park

Elephant Rocks State Park

5/5(13 reviews)

Explore the great outdoors at Elephant Rocks State Park, a lovely green space in Ironton. Make some time to visit the shops while you're in the area.

Elephant Rocks State Park
Image for Reelfoot Lake

Reelfoot Lake

4.5/5(30 reviews)

Commune with nature and explore the great outdoors at Reelfoot Lake during your travels in Tiptonville. Wander the lakeside and parks while you're in the area.

Reelfoot Lake

Frequently asked questions

How much are vacation packages to Southeast Missouri?
Epic adventures await in Southeast Missouri, with Travelocity vacation packages from as low as $256. In addition to flights and hotels, these terrific deals make it a cinch to experience more of our beautiful planet.
Where can I get the best vacation package deals for Southeast Missouri?
No matter your adventure, Travelocity can help you find the best Southeast Missouri package deal. The only thing you need to do is mix and match from our 400 partner airlines and 1,000,000 properties around the world.
Why should I book my Southeast Missouri vacation bundle via Travelocity?
With our Price Match Guarantee, we’ll match any lower price you can find. Add to that our 24/7 support and exceptional service and your dream vacation is closer than ever before.
Can I save money on my Southeast Missouri car rental if I book it with my hotel or flight?
Combining your bookings into a Southeast Missouri vacation package will leave you with some serious savings. You can book a flight and car; a car, hotel and flight; or a hotel and car. There’s no better way to explore the greater Southeast Missouri region than with your own rental car. You can also add experiences and tours to your Travelocity package.
What is the best time of year to go to Southeast Missouri?
June, July and August are the months when most travelers visit, while February, November and December are generally quieter. If your budget is a bit tight, think about visiting in . is typically the costliest time to stay here.
Which airport is best for Southeast Missouri?
Most Southeast Missouri vacationers touch down at Cape Girardeau Municipal Airport (CGI).